MutationExplorer
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  • upload structure and mutations
  • upload vcf
  • tutorials
  • examples
  • faq
  • documentation
  • contact

Select i

Select a variant to be displayed

First you select the variant to be displayed from the list.
mut_0: is the original protein that you uploaded
mut_0_1: the first mutation you applied to the original model (this was created during first upload)
mut_0_1_1: would be a further mutation applied to mut_0_1
mut_0_2: the second independent mutation applied to mut_0
The last variant created is displayed by default.

Select coloring scheme

You can color either by energy or by hydrophobicity.
For each you can choose between the difference of mutated to original or the absolute value.
The default is coloring by energy difference.

For each combination variant/coloring, there is a PDB file in the download.
The values used for the coloring are written in beta-factor column, respectively.

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Mutate

Mutate current model

First, select the model you want to mutate in the section 'Select'.
Then you can mutate the current model using the syntax:
CHAIN ':' PDB-RESIDUE-ID AA-TYPE
Separate multiple mutations with commas.
Example: 'A:12G,B:123A'
This would mutate residue with the PDB residue ID 12 in chain A to glycine and residue with the ID 123 in chain B to alanine.

Available PDB chains

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Info

Additional information about the current model

First, the parent of the current model is listed.
Second, the mutations applied to the parent are listed.
Third, the job ID is listed.

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Please cite: https://doi.org/10.1093/nar/gkae301